genbio-ai / genbio-pathfm

GenBio-PathFM

GenBio-PathFM is a histopathology foundation (FM) model from GenBio AI .

At the time of release, GenBio-PathFM is the strongest open-weight histopathology FM and the only state-of-the-art histopathology FM trained exclusively on publicly available data.

Please see GitHub for the model implementation and inference examples.

For more details:

• GenBio AI Blog Post
• Paper

Abstract

Recent advancements in histopathology foundation models (FMs) have largely been driven by scaling the training data, often utilizing massive proprietary datasets. However, the long-tailed distribution of morphological features in whole-slide images (WSIs) makes simple scaling inefficient, as common morphologies dominate the learning signal. We introduce GenBio-PathFM, a 1.1B-parameter FM that achieves state-of-the-art performance on public benchmarks while using a fraction of the training data required by current leading models. The efficiency of GenBio-PathFM is underpinned by two primary innovations: an automated data curation pipeline that prioritizes morphological diversity and a novel dual-stage learning strategy which we term JEDI ( JE PA + DI NO). Across the THUNDER, HEST, and PathoROB benchmarks, GenBio-PathFM demonstrates state-of-the-art accuracy and robustness. GenBio-PathFM is the strongest open-weight model to date and the only state-of-the-art model trained exclusively on public data.

License

GenBio-PathFM is available under the GenBio AI Community License .

Reference

If you find our work useful, consider citing our paper:

@article{kapse2026genbiopathfm,
  title={GenBio-PathFM: A State-of-the-Art Foundation Model for Histopathology},
  author={Kapse, Saarthak and Aygün, Mehmet and Cole, Elijah and Lundberg, Emma and Song, Le and Xing, Eric P.},
  journal={bioRxiv},
  year={2026}
}