MeMDLM: De Novo Membrane Protein Design with Masked Discrete Diffusion Language Models
Masked Diffusion Language Models (MDLMs)
, introduced by Sahoo et al, provide strong generative capabilities to BERT-style models. In this work, we pre-train and fine-tune ESM-2-150M protein language model (pLM) on the MDLM objective to scaffold functional motifs and unconditionally generate realistic, high-quality membrane protein sequences.
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