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ChatterjeeLab / PPI-Llama2
Model's Last Updated: May 01 2024
Introduction of PPI-Llama2
Model Details of PPI-Llama2
PPI-Llama2:
De Novo
Generation of Binding Proteins Conditioned on Target Sequence Alone
The targeting of disease-driving proteins is a critical goal of biomedicine. However, many of these proteins do not possess accessible small molecule binding pockets and are oftentimes conformationally disordered, precluding binder design via structure-dependent methods. Here, we present PPI-Llama2 , which leverages Meta's Llama2 autoregressive language model architecture to de novo generate protein binders conditioned directly on target sequences. Without relying on structural data and training only on protein-protein interaction (PPI) sequences, PPI-Llama2 effectively learns the evolutionary semantics of PPIs, enabling the generation of both novel and biologically-plausible binders.
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Updated:August 25 2025
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