An AI-powered design tool for creating publication-ready animal research protocols compliant with ARRIVE 2.0 standards.
Install & Download
1. ClawHub CLI
The fastest way to install a skill directly from the registry.
npx clawhub@latest install arrive-guideline-architect
2. Manual Installation
Copy the skill folder to one of these locations
~/.openclaw/skills/ <project>/skills/ Priority: Workspace > Local > Bundled
3. Prompt Installation
Copy this prompt to OpenClaw to install it automatically.
Help me install arrive-guideline-architect using Clawhub. If Clawhub is not installed, install it first (npm i -g clawhub).
Prefer to download?
Get the raw skill files in a ZIP archive.
What is ARRIVE Guideline Architect?
The ARRIVE Guideline Architect is a specialized technical assistant designed to streamline the creation of structured, ethical, and reproducible in vivo study protocols. By integrating the ARRIVE 2.0 (Animal Research: Reporting of In Vivo Experiments) guidelines, this skill ensures that researchers meet the rigorous transparency standards required by top-tier journals and institutional ethics committees.
This tool within the Openclaw Skills ecosystem helps researchers minimize bias and optimize experimental design through automated sample size calculations, randomization strategies, and comprehensive checklist validation. It effectively bridges the gap between study conception and formal ethics submission or manuscript preparation, ensuring all animal research follows the 3Rs principles.
ARRIVE Guideline Architect Use Cases
- Designing new animal research studies that require high levels of ethical approval and rigorous scientific structure.
- Preparing IACUC (Institutional Animal Care and Use Committee) applications with automated animal welfare documentation.
- Validating existing research protocols against the ARRIVE Essential 10 standards to ensure completeness before publication.
- Generating statistically sound randomization and blinding schemes to prevent observer and selection bias in complex studies.
- Writing high-quality manuscripts for scientific journals that mandate strict ARRIVE compliance for transparency.
How ARRIVE Guideline Architect Works
- The user provides core study parameters such as species, strain, experimental groups, and primary endpoints via a JSON configuration or interactive wizard.
- The skill performs a statistical power analysis to calculate the required sample size, specifically accounting for effect size, alpha, and expected animal dropout rates.
- A comprehensive protocol is generated automatically, covering experimental procedures, inclusion/exclusion criteria, and primary/secondary outcome measures.
- The tool produces randomization tables and blinding keys using specified seeds to ensure experimental integrity and reproducibility.
- Finally, the skill runs a compliance check against the latest ARRIVE 2.0 guidelines and exports the final protocol package in Markdown, PDF, or Word format.
ARRIVE Guideline Architect Setup
To begin using this skill within your Openclaw Skills environment, ensure you have the Python dependencies installed for statistical calculations. You can run the builder via the CLI for either automated batch processing or guided interactive setup.
# Generate a protocol from a JSON configuration file
python scripts/main.py --input study_brief.json --output protocol.md
# Launch the interactive wizard for guided study design
python scripts/main.py --interactive
# Validate an existing protocol against ARRIVE 2.0 standards
python scripts/validate.py --input my_protocol.md --format markdown
ARRIVE Guideline Architect Data Schema & Taxonomy
The ARRIVE Guideline Architect organizes data through structured JSON inputs and generates a multi-file output package to ensure full transparency and data persistence.
| File Name | Format | Description |
|---|---|---|
| protocol.md | Markdown | The complete ARRIVE 2.0 compliant research document. |
| allocation.csv | CSV | The randomization table for animal group assignment. |
| sample_size_justification.txt | Text | Statistical rationale including power analysis parameters. |
| compliance_report.pdf | A formal validation report against the Essential 10 checklist. | |
| blinding_key.xlsx | Excel | Documentation for maintaining blinded outcome assessments. |
ARRIVE Guideline Architect Advanced Features
- Automated sample size justification text generation based on Cohen's d, odds ratios, or hazard ratios.
- Support for advanced randomization methods including block randomization, stratified randomization, and covariate-adaptive minimization.
- Upstream and downstream integration hooks for sample size calculators and manuscript preparation assistants.
- Custom validation levels to support specific publisher requirements or institutional ethics committee standards.
- Integrated templates for common study patterns such as toxicology assessments, behavioral neuroscience, and surgical models.
SKILL.md
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