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Whole-blood DNA-methylation predictor of intrinsic capacity, an average score across cognition, locomotion, psychological, sensory, and vitality domains; trained with tenfold cross-validated elastic net on INSPIRE-T and returning higher values for better capacity.
Predicts
intrinsic capacity
Species
Homo sapiens
Tissue
whole blood
Data type
DNA methylation
Model type
elastic net regression
Year
2025
Use with pyaging
import pyaging as pya
pya.pred.predict_age(adata, ["dnamic"])
Fuentealba, M., Rouch, L., Guyonnet, S. et al. A blood-based epigenetic clock for intrinsic capacity predicts mortality and is associated with clinical, immunological and lifestyle factors. Nature Aging 5, 1207–1216 (2025).
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