Create React App is a tool that sets up a modern React application by providing a preconfigured development environment with build scripts, modules, and dependencies. It abstracts away complex configurations and allows developers to focus on building their applications.
To use Create React App, you need to have Node.js and npm (Node Package Manager) installed on your machine. Simply install Create React App globally using npm, and then run 'create-react-app' followed by the name of your project. This will generate a new React application with all the necessary files and folder structure.